Assay Detail
Binding
CHEMBL828076
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Inhibitory activity against coagulation factor II (thrombin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.30 | 5.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182746 | — | — | 1 | 5.56 |
| CHEMBL181849 | — | — | 1 | 5.04 |
| CHEMBL368238 | — | — | 1 | - |
| CHEMBL182597 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182746 | — | Ki | = | 2760.0 | nM | 5.56 |
| CHEMBL181849 | — | Ki | = | 9040.0 | nM | 5.04 |
| CHEMBL368238 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL182597 | — | Ki | > | 10000.0 | nM | - |