Assay Detail
Binding
CHEMBL828106
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Inhibition of [3H]FPP incorporation into recombinant Ras CVIM by human Farnesyltransferase
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 9.49 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361246 | — | — | 1 | 11.00 |
| CHEMBL426063 | — | — | 1 | 10.52 |
| CHEMBL364792 | — | — | 1 | 10.00 |
| CHEMBL184707 | — | — | 1 | 9.57 |
| CHEMBL435285 | — | — | 1 | 9.51 |
| CHEMBL184330 | — | — | 1 | 9.44 |
| CHEMBL186906 | — | — | 1 | 9.43 |
| CHEMBL181748 | — | — | 1 | 9.43 |
| CHEMBL22702 | — | — | 1 | 9.43 |
| CHEMBL187175 | — | — | 1 | 9.34 |
| CHEMBL364165 | — | — | 1 | 9.22 |
| CHEMBL362881 | — | — | 1 | 9.21 |
| CHEMBL24043 | — | — | 1 | 9.14 |
| CHEMBL184568 | — | — | 1 | 8.92 |
| CHEMBL187375 | — | — | 1 | 8.92 |
| CHEMBL187809 | — | — | 1 | 8.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361246 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL426063 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL364792 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL184707 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL435285 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL184330 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL186906 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL181748 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL22702 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL187175 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL364165 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL362881 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL24043 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL184568 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL187375 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL187809 | — | IC50 | = | 2.1 | nM | 8.68 |