Compound Detail
CHEMBL187375
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Basic Information
| ChEMBL ID | CHEMBL187375 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZGBJQRVUJIKBSE-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
444.5
MW (Da)
4.44
ALogP
6
HBA
1
HBD
94.9
PSA (Ų)
0.46
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.92
EC50 1 meas. best 7.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 8.92 | 8.92 | 1.2 | 1 |
| Protein farnesyltransferase CHEMBL2096912 | EC50 | 7.24 | 7.24 | 57.5 | 1 |
| Geranylgeranyl transferase type I CHEMBL2095164 | IC50 | 4.92 | 4.92 | 12000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 1.2 | nM | 8.92 | Inhibition of [3H]FPP incorporation into recombinant Ras CVIM by human Farnesylt... | 15380198 |
| Protein farnesyltransferase | EC50 | = | 57.5 | nM | 7.24 | Reduced farnesylation in H-Ras NIH3T3 cells | 15380198 |
| Geranylgeranyl transferase type I | IC50 | = | 12000.0 | nM | 4.92 | Inhibition of [3H]GGPP incorporation into C-terminus of K-Ras by human Geranylge... | 15380198 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15380198 | 10.1016/j.bmcl.2004.07.083 | Protein farnesyltransferase | 2 |
| 15380198 | 10.1016/j.bmcl.2004.07.083 | Geranylgeranyl transferase type I | 1 |
| 15380198 | 10.1016/j.bmcl.2004.07.083 | Protein farnesyl/geranylgeranyl transferase | 1 |
Data from ChEMBL 36 via Core Engine