Assay Detail
Binding
CHEMBL832329
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Inhibition of [3H]GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Geranylgeranyl transferase type I (CHEMBL2095164) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.46 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184330 | — | — | 1 | 6.06 |
| CHEMBL181748 | — | — | 1 | 6.00 |
| CHEMBL426063 | — | — | 1 | 5.96 |
| CHEMBL362881 | — | — | 1 | 5.89 |
| CHEMBL184568 | — | — | 1 | 5.64 |
| CHEMBL24043 | — | — | 1 | 5.62 |
| CHEMBL361246 | — | — | 1 | 5.58 |
| CHEMBL184707 | — | — | 1 | 5.50 |
| CHEMBL364792 | — | — | 1 | 5.50 |
| CHEMBL22702 | — | — | 1 | 5.39 |
| CHEMBL364165 | — | — | 1 | 5.18 |
| CHEMBL186906 | — | — | 1 | 5.17 |
| CHEMBL187175 | — | — | 1 | 5.00 |
| CHEMBL435285 | — | — | 1 | 5.00 |
| CHEMBL187809 | — | — | 1 | 5.00 |
| CHEMBL187375 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184330 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL181748 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL426063 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL362881 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL184568 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL24043 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL361246 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL184707 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL364792 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL22702 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL364165 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL186906 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL187175 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL435285 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL187809 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL187375 | — | IC50 | = | 12000.0 | nM | 4.92 |