Assay Detail
Binding
CHEMBL828107
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]AMPA from Ionotropic glutamate receptor of in rat brain synaptosomes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.23 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370038 | — | — | 1 | 8.05 |
| CHEMBL276815 | (S)-AMPA | — | 1 | 7.68 |
| CHEMBL94859 | — | — | 1 | 7.57 |
| CHEMBL370941 | — | — | 1 | 6.87 |
| CHEMBL372643 | — | — | 1 | 5.60 |
| CHEMBL193087 | — | — | 1 | 5.21 |
| CHEMBL194226 | — | — | 1 | 4.57 |
| CHEMBL317790 | — | — | 1 | 4.27 |
| CHEMBL371784 | — | — | 1 | - |
| CHEMBL363422 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370038 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL276815 | (S)-AMPA | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL94859 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL370941 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL372643 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL193087 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL194226 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL317790 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL371784 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL363422 | — | IC50 | > | 100000.0 | nM | - |