Compound Detail
CHEMBL194226
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Basic Information
| ChEMBL ID | CHEMBL194226 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FMKVWGBJZLZPFM-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
268.2
MW (Da)
-0.99
ALogP
9
HBA
3
HBD
153.2
PSA (Ų)
0.62
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 4.57 | 4.57 | 27000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 27000.0 | nM | 4.57 | Displacement of [3H]AMPA from Ionotropic glutamate receptor of in rat brain syna... | 15857151 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15857151 | 10.1021/jm050014l | Glutamate receptor ionotropic, AMPA | 1 |
| 15857151 | 10.1021/jm050014l | Glutamate receptor ionotropic, kainate | 1 |
| 15857151 | 10.1021/jm050014l | Glutamate NMDA receptor | 1 |
| 15857151 | 10.1021/jm050014l | Glutamate receptor ionotropic, kainate 3 | 1 |
Data from ChEMBL 36 via Core Engine