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Assay Detail

CHEMBL828122

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of putrescine binding to against Diamine oxidase of porcine kidney
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Diamine oxidase [copper-containing] (CHEMBL2118)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Alkylamino derivatives of 4-aminomethylpyridine as inhibitors of copper-containing amine oxidases.
Bertini V, Buffoni F, Ignesti G, Picci N, Trombino S, Iemma F, Alfei S, Pocci M, Lucchesini F, De Munno A.
J Med Chem (2005) 48 : 664 -670
PubMed 15689151 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.71 7.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL534467 1 7.21
CHEMBL537845 1 6.92
CHEMBL534914 1 6.80
CHEMBL536953 1 6.52
CHEMBL537624 1 6.30
CHEMBL537405 1 6.00
CHEMBL537623 1 5.60
CHEMBL537174 1 5.30
CHEMBL537406 1 5.00
CHEMBL557160 1 4.80
CHEMBL537628 1 4.75
CHEMBL537402 1 4.72
CHEMBL541126 1 4.30
CHEMBL559376 1 -
CHEMBL536949 1 -
CHEMBL537401 1 -
CHEMBL536719 1 -
CHEMBL536484 1 -
CHEMBL536951 1 -
CHEMBL538353 1 -
CHEMBL539362 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL534467 IC50 = 61.0 nM 7.21
CHEMBL537845 IC50 = 120.0 nM 6.92
CHEMBL534914 IC50 = 160.0 nM 6.80
CHEMBL536953 IC50 = 300.0 nM 6.52
CHEMBL537624 IC50 = 500.0 nM 6.30
CHEMBL537405 IC50 = 1000.0 nM 6.00
CHEMBL537623 IC50 = 2500.0 nM 5.60
CHEMBL537174 IC50 = 5000.0 nM 5.30
CHEMBL537406 IC50 = 10000.0 nM 5.00
CHEMBL557160 IC50 = 16000.0 nM 4.80
CHEMBL537628 IC50 = 18000.0 nM 4.75
CHEMBL537402 IC50 = 19000.0 nM 4.72
CHEMBL541126 IC50 = 50000.0 nM 4.30
CHEMBL559376 IC50 > 100000.0 nM -
CHEMBL536949 IC50 > 100000.0 nM -
CHEMBL537401 IC50 > 1000000.0 nM -
CHEMBL536719 IC50 > 1000000.0 nM -
CHEMBL536484 IC50 > 1000000.0 nM -
CHEMBL536951 IC50 > 1000000.0 nM -
CHEMBL538353 IC50 = 1000000.0 nM -
CHEMBL539362 IC50 > 1000000.0 nM -