Assay Detail
Binding
CHEMBL828171
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against mouse Melanin-concentrating hormone receptor 1 expressed in IMR-32 cells using [125I]MCH
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | IMR-32 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL4730) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis and evaluation of urea-based indazoles as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.98 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196388 | — | — | 1 | 8.74 |
| CHEMBL196599 | — | — | 1 | 8.62 |
| CHEMBL195914 | — | — | 1 | 8.23 |
| CHEMBL197210 | — | — | 1 | 8.07 |
| CHEMBL426292 | — | — | 1 | 7.92 |
| CHEMBL425013 | — | — | 1 | 7.70 |
| CHEMBL195319 | — | — | 1 | 7.46 |
| CHEMBL364071 | — | — | 1 | 7.41 |
| CHEMBL197571 | — | — | 1 | 7.39 |
| CHEMBL370839 | — | — | 1 | 7.38 |
| CHEMBL196839 | — | — | 1 | 7.11 |
| CHEMBL196115 | — | — | 1 | 7.08 |
| CHEMBL424836 | — | — | 1 | 7.04 |
| CHEMBL372570 | — | — | 1 | 6.95 |
| CHEMBL197054 | — | — | 1 | 6.87 |
| CHEMBL196332 | — | — | 1 | 6.52 |
| CHEMBL196781 | — | — | 1 | 6.29 |
| CHEMBL196390 | — | — | 1 | 6.26 |
| CHEMBL372291 | — | — | 1 | 6.24 |
| CHEMBL196991 | — | — | 1 | 6.01 |
| CHEMBL425744 | — | — | 1 | 5.98 |
| CHEMBL383798 | — | — | 1 | 5.73 |
| CHEMBL364936 | — | — | 1 | 5.35 |
| CHEMBL195896 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196388 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL196599 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL195914 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL197210 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL426292 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL425013 | — | IC50 | = | 19.8 | nM | 7.70 |
| CHEMBL195319 | — | IC50 | = | 34.3 | nM | 7.46 |
| CHEMBL364071 | — | IC50 | = | 38.7 | nM | 7.41 |
| CHEMBL197571 | — | IC50 | = | 40.6 | nM | 7.39 |
| CHEMBL370839 | — | IC50 | = | 41.3 | nM | 7.38 |
| CHEMBL196839 | — | IC50 | = | 78.5 | nM | 7.11 |
| CHEMBL196115 | — | IC50 | = | 82.9 | nM | 7.08 |
| CHEMBL424836 | — | IC50 | = | 91.5 | nM | 7.04 |
| CHEMBL372570 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL197054 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL196332 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL196781 | — | IC50 | = | 508.0 | nM | 6.29 |
| CHEMBL196390 | — | IC50 | = | 545.0 | nM | 6.26 |
| CHEMBL372291 | — | IC50 | = | 581.0 | nM | 6.24 |
| CHEMBL196991 | — | IC50 | = | 971.0 | nM | 6.01 |
| CHEMBL425744 | — | IC50 | = | 1053.0 | nM | 5.98 |
| CHEMBL383798 | — | IC50 | = | 1851.0 | nM | 5.73 |
| CHEMBL364936 | — | IC50 | = | 4509.0 | nM | 5.35 |
| CHEMBL195896 | — | IC50 | = | 6130.0 | nM | 5.21 |