Assay Detail
Binding
CHEMBL828177
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition constant against rabbit liver carboxylesterase using 4-MUA (4-methylumbelliferone acetate)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.68 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193228 | — | — | 1 | 9.77 |
| CHEMBL192139 | — | — | 1 | 8.89 |
| CHEMBL192180 | — | — | 1 | 8.77 |
| CHEMBL362996 | — | — | 1 | 8.68 |
| CHEMBL191847 | — | — | 1 | 8.40 |
| CHEMBL193140 | — | — | 1 | 8.36 |
| CHEMBL189886 | BENZIL | — | 1 | 7.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193228 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL192139 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL192180 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL362996 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL191847 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL193140 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL189886 | BENZIL | Ki | = | 13.6 | nM | 7.87 |