Assay Detail
Binding
CHEMBL828216
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against human thrombin
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 5.89 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179964 | — | — | 1 | 7.47 |
| CHEMBL179213 | — | — | 1 | 6.70 |
| CHEMBL558198 | RAZAXABAN HYDROCHLORIDE | -1.0 | 1 | 6.22 |
| CHEMBL179665 | — | — | 1 | 6.22 |
| CHEMBL368285 | — | — | 1 | 6.13 |
| CHEMBL368927 | — | — | 1 | 6.10 |
| CHEMBL179410 | — | — | 1 | 6.05 |
| CHEMBL175449 | — | — | 1 | 6.05 |
| CHEMBL176494 | — | — | 1 | 6.05 |
| CHEMBL355576 | — | — | 1 | 6.05 |
| CHEMBL445391 | — | — | 1 | 5.96 |
| CHEMBL426957 | — | — | 1 | 5.77 |
| CHEMBL367954 | — | — | 1 | 5.77 |
| CHEMBL425512 | — | — | 1 | 5.64 |
| CHEMBL361846 | — | — | 1 | 5.46 |
| CHEMBL176140 | — | — | 1 | 5.22 |
| CHEMBL554926 | — | — | 1 | 5.20 |
| CHEMBL359695 | — | — | 1 | 5.10 |
| CHEMBL175779 | — | — | 1 | 4.70 |
| CHEMBL176157 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179964 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL179213 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL558198 | RAZAXABAN HYDROCHLORIDE | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL179665 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL368285 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL368927 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL179410 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL175449 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL176494 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL355576 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL445391 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL426957 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL367954 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL425512 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL361846 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL176140 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL554926 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL359695 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL175779 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL176157 | — | Ki | > | 21000.0 | nM | - |