Assay Detail
Binding
CHEMBL828219
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Inhibition constant against human carbonic anhydrase I
29
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 7.35 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3038232 | — | — | 1 | 8.00 |
| CHEMBL3038238 | — | — | 1 | 7.92 |
| CHEMBL3038236 | — | — | 2 | 7.89 |
| CHEMBL3038242 | — | — | 1 | 7.85 |
| CHEMBL3038239 | — | — | 1 | 7.82 |
| CHEMBL3038241 | — | — | 1 | 7.68 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL197104 | — | — | 1 | 7.54 |
| CHEMBL197031 | — | — | 1 | 7.52 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.51 |
| CHEMBL372497 | — | — | 1 | 7.50 |
| CHEMBL373184 | — | — | 1 | 7.46 |
| CHEMBL3038240 | — | — | 1 | 7.44 |
| CHEMBL195615 | — | — | 1 | 7.43 |
| CHEMBL193907 | — | — | 1 | 7.36 |
| CHEMBL3038234 | — | — | 1 | 7.29 |
| CHEMBL3038237 | — | — | 1 | 7.27 |
| CHEMBL381243 | — | — | 1 | 7.21 |
| CHEMBL3038233 | — | — | 1 | 7.21 |
| CHEMBL196697 | — | — | 1 | 7.07 |
| CHEMBL193924 | — | — | 1 | 7.03 |
| CHEMBL196608 | — | — | 1 | 7.00 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.55 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 5.92 |
| CHEMBL193593 | — | — | 1 | - |
| CHEMBL370790 | — | — | 1 | - |
| CHEMBL3038235 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3038232 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3038238 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3038236 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL3038242 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL3038239 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL3038241 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL197104 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL197031 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL77517 | INDISULAM | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL372497 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL373184 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL3038240 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL195615 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL193907 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL3038234 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL3038237 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL381243 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL3038233 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL196697 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL193924 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL196608 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL193593 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL370790 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3038235 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3038236 | — | Ki | > | 1000.0 | nM | - |