Assay Detail
Binding
CHEMBL828235
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Phosphodiesterase 5 purified from MCF-7 cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.93 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184017 | — | — | 1 | 5.40 |
| CHEMBL182227 | — | — | 1 | 5.29 |
| CHEMBL185203 | — | — | 1 | 5.16 |
| CHEMBL185604 | — | — | 1 | 5.14 |
| CHEMBL263311 | — | — | 1 | 5.12 |
| CHEMBL185532 | — | — | 1 | 4.96 |
| CHEMBL182574 | — | — | 1 | 4.75 |
| CHEMBL184837 | — | — | 1 | 4.73 |
| CHEMBL360874 | — | — | 1 | 4.70 |
| CHEMBL363673 | — | — | 1 | 4.63 |
| CHEMBL183156 | — | — | 1 | 4.39 |
| CHEMBL365206 | — | — | 1 | - |
| CHEMBL361512 | — | — | 1 | - |
| CHEMBL184960 | — | — | 1 | - |
| CHEMBL363709 | — | — | 1 | - |
| CHEMBL185531 | — | — | 1 | - |
| CHEMBL362719 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184017 | — | IC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL182227 | — | IC50 | = | 5180.0 | nM | 5.29 |
| CHEMBL185203 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL185604 | — | IC50 | = | 7270.0 | nM | 5.14 |
| CHEMBL263311 | — | IC50 | = | 7560.0 | nM | 5.12 |
| CHEMBL185532 | — | IC50 | = | 10940.0 | nM | 4.96 |
| CHEMBL182574 | — | IC50 | = | 17880.0 | nM | 4.75 |
| CHEMBL184837 | — | IC50 | = | 18770.0 | nM | 4.73 |
| CHEMBL360874 | — | IC50 | = | 20160.0 | nM | 4.70 |
| CHEMBL363673 | — | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL183156 | — | IC50 | = | 40350.0 | nM | 4.39 |
| CHEMBL365206 | — | IC50 | > | 101000.0 | nM | - |
| CHEMBL361512 | — | IC50 | > | 101000.0 | nM | - |
| CHEMBL184960 | — | IC50 | > | 101000.0 | nM | - |
| CHEMBL363709 | — | IC50 | > | 101000.0 | nM | - |
| CHEMBL185531 | — | IC50 | > | 101000.0 | nM | - |
| CHEMBL362719 | — | IC50 | = | 101000.0 | nM | - |