Compound Detail
CHEMBL185203
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Basic Information
| ChEMBL ID | CHEMBL185203 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SKVDDXFAECGHTI-VLGSPTGOSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
369.8
MW (Da)
3.21
ALogP
7
HBA
1
HBD
84.6
PSA (Ų)
0.60
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| High affinity 3',5'-cyclic-AMP phosphodiesterase 7A CHEMBL3012 | IC50 | 7.1 | 7.1 | 80.0 | 1 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A CHEMBL241 | IC50 | 5.77 | 5.77 | 1710.0 | 1 |
| Phosphodiesterase 1 CHEMBL2095150 | IC50 | 5.48 | 5.48 | 3340.0 | 1 |
| 3',5'-cyclic-AMP phosphodiesterase 4D CHEMBL288 | IC50 | 5.37 | 5.37 | 4260.0 | 1 |
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL1827 | IC50 | 5.16 | 5.16 | 7000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| High affinity 3',5'-cyclic-AMP phosphodiesterase 7A | IC50 | = | 80.0 | nM | 7.1 | Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 ... | 15324874 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A | IC50 | = | 1710.0 | nM | 5.77 | Inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 ... | 15324874 |
| Phosphodiesterase 1 | IC50 | = | 3340.0 | nM | 5.48 | Inhibition of human Phosphodiesterase 1 purified from THP-1 cells | 15324874 |
| 3',5'-cyclic-AMP phosphodiesterase 4D | IC50 | = | 4260.0 | nM | 5.37 | Inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 ... | 15324874 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 7000.0 | nM | 5.16 | Inhibition of human Phosphodiesterase 5 purified from MCF-7 cells | 15324874 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15324874 | 10.1016/j.bmcl.2004.07.008 | High affinity 3',5'-cyclic-AMP phosphodiesterase 7A | 1 |
| 15324874 | 10.1016/j.bmcl.2004.07.008 | 3',5'-cyclic-AMP phosphodiesterase 4D | 1 |
| 15324874 | 10.1016/j.bmcl.2004.07.008 | Phosphodiesterase 1 | 1 |
| 15324874 | 10.1016/j.bmcl.2004.07.008 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A | 1 |
| 15324874 | 10.1016/j.bmcl.2004.07.008 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
Data from ChEMBL 36 via Core Engine