Assay Detail
Binding
CHEMBL828294
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells
59
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 59 | 4.64 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185203 | — | — | 1 | 5.37 |
| CHEMBL263311 | — | — | 1 | 5.25 |
| CHEMBL186615 | — | — | 1 | 5.23 |
| CHEMBL184829 | — | — | 1 | 5.23 |
| CHEMBL182681 | — | — | 1 | 5.20 |
| CHEMBL184017 | — | — | 1 | 5.15 |
| CHEMBL184154 | — | — | 1 | 5.06 |
| CHEMBL183119 | — | — | 1 | 4.96 |
| CHEMBL365659 | — | — | 1 | 4.92 |
| CHEMBL185439 | — | — | 1 | 4.91 |
| CHEMBL361512 | — | — | 1 | 4.89 |
| CHEMBL182227 | — | — | 1 | 4.85 |
| CHEMBL185446 | — | — | 1 | 4.82 |
| CHEMBL184057 | — | — | 1 | 4.82 |
| CHEMBL369541 | — | — | 1 | 4.77 |
| CHEMBL182294 | — | — | 1 | 4.72 |
| CHEMBL184016 | — | — | 1 | 4.72 |
| CHEMBL183952 | — | — | 1 | 4.71 |
| CHEMBL363673 | — | — | 1 | 4.69 |
| CHEMBL185604 | — | — | 1 | 4.67 |
| CHEMBL367135 | — | — | 1 | 4.65 |
| CHEMBL359562 | — | — | 1 | 4.65 |
| CHEMBL360874 | — | — | 1 | 4.64 |
| CHEMBL185144 | — | — | 1 | 4.60 |
| CHEMBL362033 | — | — | 1 | 4.59 |
| CHEMBL363118 | — | — | 1 | 4.58 |
| CHEMBL183816 | — | — | 1 | 4.58 |
| CHEMBL184470 | — | — | 1 | 4.52 |
| CHEMBL365634 | — | — | 1 | 4.49 |
| CHEMBL187201 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185203 | — | IC50 | = | 4260.0 | nM | 5.37 |
| CHEMBL263311 | — | IC50 | = | 5630.0 | nM | 5.25 |
| CHEMBL184829 | — | IC50 | = | 5840.0 | nM | 5.23 |
| CHEMBL186615 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL182681 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL184017 | — | IC50 | = | 7050.0 | nM | 5.15 |
| CHEMBL184154 | — | IC50 | = | 8770.0 | nM | 5.06 |
| CHEMBL183119 | — | IC50 | = | 10970.0 | nM | 4.96 |
| CHEMBL365659 | — | IC50 | = | 11880.0 | nM | 4.92 |
| CHEMBL185439 | — | IC50 | = | 12230.0 | nM | 4.91 |
| CHEMBL361512 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL182227 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL185446 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL184057 | — | IC50 | = | 15050.0 | nM | 4.82 |
| CHEMBL369541 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL182294 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL184016 | — | IC50 | = | 19250.0 | nM | 4.72 |
| CHEMBL183952 | — | IC50 | = | 19330.0 | nM | 4.71 |
| CHEMBL363673 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL185604 | — | IC50 | = | 21330.0 | nM | 4.67 |
| CHEMBL367135 | — | IC50 | = | 22170.0 | nM | 4.65 |
| CHEMBL359562 | — | IC50 | = | 22250.0 | nM | 4.65 |
| CHEMBL360874 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL185144 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL362033 | — | IC50 | = | 25750.0 | nM | 4.59 |
| CHEMBL363118 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL183816 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL184470 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL365634 | — | IC50 | = | 32250.0 | nM | 4.49 |
| CHEMBL187201 | — | IC50 | = | 33330.0 | nM | 4.48 |
| CHEMBL363097 | — | IC50 | = | 34250.0 | nM | 4.46 |
| CHEMBL363709 | — | IC50 | = | 36330.0 | nM | 4.44 |
| CHEMBL363236 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL184806 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL360434 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL182574 | — | IC50 | = | 39660.0 | nM | 4.40 |
| CHEMBL184089 | — | IC50 | = | 44660.0 | nM | 4.35 |
| CHEMBL184960 | — | IC50 | = | 44500.0 | nM | 4.35 |
| CHEMBL184334 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL184837 | — | IC50 | = | 58250.0 | nM | 4.24 |
| CHEMBL361706 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL185502 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL182788 | — | IC50 | = | 81500.0 | nM | 4.09 |
| CHEMBL186868 | — | IC50 | = | 92330.0 | nM | 4.04 |
| CHEMBL362264 | — | IC50 | = | 95500.0 | nM | 4.02 |
| CHEMBL365206 | — | IC50 | > | 101000.0 | nM | - |
| CHEMBL185532 | — | IC50 | > | 101000.0 | nM | - |
| CHEMBL185531 | — | IC50 | > | 101000.0 | nM | - |
| CHEMBL365402 | — | IC50 | > | 101000.0 | nM | - |
| CHEMBL185173 | — | IC50 | > | 101000.0 | nM | - |