Assay Detail
Binding
CHEMBL828298
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (CHEMBL3012) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.23 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182703 | — | — | 1 | 8.00 |
| CHEMBL427152 | — | — | 1 | 8.00 |
| CHEMBL185370 | — | — | 1 | 7.40 |
| CHEMBL185360 | — | — | 1 | 7.22 |
| CHEMBL366319 | — | — | 1 | 7.22 |
| CHEMBL184791 | — | — | 1 | 6.92 |
| CHEMBL185019 | — | — | 1 | 6.80 |
| CHEMBL185814 | — | — | 1 | 6.80 |
| CHEMBL185460 | — | — | 1 | 6.77 |
| CHEMBL185485 | — | — | 1 | 6.68 |
| CHEMBL363075 | — | — | 1 | 6.41 |
| CHEMBL362141 | — | — | 1 | 6.22 |
| CHEMBL184081 | — | — | 1 | 6.10 |
| CHEMBL361454 | — | — | 1 | 6.08 |
| CHEMBL184781 | — | — | 1 | 6.01 |
| CHEMBL184888 | — | — | 1 | 5.85 |
| CHEMBL361048 | — | — | 1 | 5.58 |
| CHEMBL185150 | — | — | 1 | 5.57 |
| CHEMBL185241 | — | — | 1 | 5.53 |
| CHEMBL184877 | — | — | 1 | 5.50 |
| CHEMBL184153 | — | — | 1 | 5.43 |
| CHEMBL184006 | — | — | 1 | 5.32 |
| CHEMBL185120 | — | — | 1 | 5.18 |
| CHEMBL184085 | — | — | 1 | 5.18 |
| CHEMBL184600 | — | — | 1 | 5.16 |
| CHEMBL366148 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182703 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL427152 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL185370 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL185360 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL366319 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL184791 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL185019 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL185814 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL185460 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL185485 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL363075 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL362141 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL184081 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL361454 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL184781 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL184888 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL361048 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL185150 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL185241 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL184877 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL184153 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL184006 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL185120 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL184085 | — | IC50 | = | 6540.0 | nM | 5.18 |
| CHEMBL184600 | — | IC50 | = | 6850.0 | nM | 5.16 |
| CHEMBL366148 | — | IC50 | = | 9500.0 | nM | 5.02 |