Compound Detail
CHEMBL185460
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Basic Information
| ChEMBL ID | CHEMBL185460 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JYCHFFXFIDUIDW-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
250.7
MW (Da)
3.63
ALogP
1
HBA
2
HBD
41.1
PSA (Ų)
0.73
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphodiesterase 7 CHEMBL2111411 | IC50 | 6.77 | 6.77 | 170.0 | 1 |
| High affinity 3',5'-cyclic-AMP phosphodiesterase 7A CHEMBL3012 | IC50 | 6.77 | 6.77 | 170.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| High affinity 3',5'-cyclic-AMP phosphodiesterase 7A | IC50 | = | 170.0 | nM | 6.77 | Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cells | 15324877 |
| High affinity 3',5'-cyclic-AMP phosphodiesterase 7A | IC50 | = | 170.0 | nM | 6.77 | Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 ... | 15324876 |
| Phosphodiesterase 7 | IC50 | = | 170.0 | nM | 6.77 | Inhibition of recombinant PDE7 (unknown origin) expressed in Escherichia coli BL... | 36796299 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15324877 | 10.1016/j.bmcl.2004.07.010 | High affinity 3',5'-cyclic-AMP phosphodiesterase 7A | 1 |
| 15324876 | 10.1016/j.bmcl.2004.07.011 | High affinity 3',5'-cyclic-AMP phosphodiesterase 7A | 1 |
| 36796299 | 10.1016/j.ejmech.2023.115194 | Phosphodiesterase 7 | 1 |
Data from ChEMBL 36 via Core Engine