Assay Detail
Binding
CHEMBL828340
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of rat platelet 12-lipoxygenase
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.55 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301253 | — | — | 1 | 6.52 |
| CHEMBL55053 | — | — | 1 | 6.40 |
| CHEMBL53028 | — | — | 1 | 6.30 |
| CHEMBL54453 | — | — | 1 | 6.30 |
| CHEMBL54013 | — | — | 1 | 6.22 |
| CHEMBL54360 | — | — | 1 | 6.00 |
| CHEMBL52748 | — | — | 1 | 5.82 |
| CHEMBL54429 | — | — | 1 | 5.82 |
| CHEMBL53393 | — | — | 1 | 5.82 |
| CHEMBL55762 | — | — | 1 | 5.82 |
| CHEMBL52896 | — | — | 1 | 5.70 |
| CHEMBL55133 | — | — | 1 | 5.70 |
| CHEMBL55620 | — | — | 1 | 5.60 |
| CHEMBL293264 | — | — | 1 | 5.60 |
| CHEMBL52085 | — | — | 1 | 5.52 |
| CHEMBL54838 | — | — | 1 | 5.46 |
| CHEMBL52241 | — | — | 1 | 5.35 |
| CHEMBL52572 | — | — | 1 | 5.30 |
| CHEMBL415963 | — | — | 1 | 5.00 |
| CHEMBL55895 | PHENYLBUTYRYLHYDROXAMIC ACID | — | 1 | 4.82 |
| CHEMBL54438 | — | — | 1 | 4.82 |
| CHEMBL51687 | — | — | 1 | 4.68 |
| CHEMBL55844 | — | — | 1 | 4.40 |
| CHEMBL444315 | — | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301253 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL55053 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL53028 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL54453 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL54013 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL54360 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL52748 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL54429 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL53393 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL55762 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL52896 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL55133 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL55620 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL293264 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL52085 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL54838 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL52241 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL52572 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL415963 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL55895 | PHENYLBUTYRYLHYDROXAMIC ACID | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL54438 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL51687 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL55844 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL444315 | — | IC50 | = | 65000.0 | nM | 4.19 |