Assay Detail
Binding
CHEMBL828395
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In vitro inhibitory concentration against human protein kinase C alpha (PKCa) by using [gamma-33P]-ATP] as radioligand
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent inhibition of checkpoint kinase activity by a hymenialdisine-derived indoloazepine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.88 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361708 | HYMENIALDISINE | — | 1 | 6.16 |
| CHEMBL332551 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361708 | HYMENIALDISINE | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL332551 | — | IC50 | = | 2539.0 | nM | 5.59 |