Assay Detail
Binding
CHEMBL828409
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Inhibitory concentration against adenosine deaminase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Rational design of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors: predicting enzyme conformational change and metabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.47 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340297 | — | — | 1 | 8.17 |
| CHEMBL359803 | — | — | 1 | 8.07 |
| CHEMBL436332 | — | — | 1 | 8.06 |
| CHEMBL328139 | — | — | 1 | 7.82 |
| CHEMBL93560 | — | — | 1 | 7.80 |
| CHEMBL327830 | — | — | 1 | 6.24 |
| CHEMBL93647 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340297 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL359803 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL436332 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL328139 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL93560 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL327830 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL93647 | — | IC50 | = | 700.0 | nM | 6.16 |