Assay Detail
Binding
CHEMBL828450
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Inhibition of biotinylated lamin B peptide farnesylation by rat farnesyltransferase
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Protein farnesyltransferase (CHEMBL2095197) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.20 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL181102 | — | — | 1 | 9.15 |
| CHEMBL193034 | — | — | 1 | 9.10 |
| CHEMBL182888 | — | — | 1 | 8.92 |
| CHEMBL183536 | — | — | 1 | 8.92 |
| CHEMBL194447 | — | — | 1 | 8.82 |
| CHEMBL373337 | — | — | 1 | 8.74 |
| CHEMBL365742 | — | — | 1 | 8.52 |
| CHEMBL370298 | — | — | 1 | 8.49 |
| CHEMBL191843 | — | — | 1 | 8.47 |
| CHEMBL192244 | — | — | 1 | 8.42 |
| CHEMBL192898 | — | — | 1 | 8.30 |
| CHEMBL195168 | — | — | 1 | 8.22 |
| CHEMBL195597 | — | — | 1 | 8.12 |
| CHEMBL365549 | — | — | 1 | 8.00 |
| CHEMBL372017 | — | — | 1 | 6.80 |
| CHEMBL371408 | — | — | 1 | 6.36 |
| CHEMBL193161 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL181102 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL193034 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL182888 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL183536 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL194447 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL373337 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL365742 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL370298 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL191843 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL192244 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL192898 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL195168 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL195597 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL365549 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL372017 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL371408 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL193161 | — | IC50 | = | 1000.0 | nM | 6.00 |