Assay Detail
Binding
CHEMBL828503
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Inhibitory concentration against MMP-1
24
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of 3-OH-3-methylpipecolic hydroxamates: potent orally active inhibitors of aggrecanase and MMP-13.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.20 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL446697 | — | — | 1 | 6.92 |
| CHEMBL360854 | — | — | 1 | 6.92 |
| CHEMBL182306 | — | — | 1 | 6.75 |
| CHEMBL365247 | — | — | 1 | 6.72 |
| CHEMBL365283 | — | — | 1 | 6.66 |
| CHEMBL183474 | — | — | 1 | 6.57 |
| CHEMBL187092 | — | — | 1 | 6.51 |
| CHEMBL186663 | — | — | 1 | 6.51 |
| CHEMBL369115 | — | — | 1 | 6.47 |
| CHEMBL183995 | — | — | 2 | 6.38 |
| CHEMBL365658 | — | — | 1 | 6.30 |
| CHEMBL187474 | — | — | 1 | 6.28 |
| CHEMBL186500 | — | — | 1 | 6.22 |
| CHEMBL187245 | — | — | 1 | 6.07 |
| CHEMBL435102 | — | — | 1 | 5.96 |
| CHEMBL185168 | — | — | 1 | 5.96 |
| CHEMBL363126 | — | — | 1 | 5.89 |
| CHEMBL186743 | — | — | 1 | 5.80 |
| CHEMBL187141 | — | — | 1 | 5.80 |
| CHEMBL187852 | — | — | 1 | 5.58 |
| CHEMBL426975 | — | — | 1 | 5.57 |
| CHEMBL364643 | — | — | 1 | 5.54 |
| CHEMBL436277 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL446697 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL360854 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL182306 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL365247 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL365283 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL183474 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL187092 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL186663 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL369115 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL183995 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL183995 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL365658 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL187474 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL186500 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL187245 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL435102 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL185168 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL363126 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL186743 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL187141 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL187852 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL426975 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL364643 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL436277 | — | IC50 | = | 7800.0 | nM | 5.11 |