Assay Detail
Binding
CHEMBL828519
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Inhibitory activity against recombinant human Caspase-1
30
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.34 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183619 | — | — | 1 | 6.17 |
| CHEMBL183109 | — | — | 2 | 5.99 |
| CHEMBL183379 | — | — | 1 | 5.81 |
| CHEMBL361111 | — | — | 1 | 5.61 |
| CHEMBL182095 | — | — | 1 | 5.52 |
| CHEMBL82932 | — | — | 2 | 5.52 |
| CHEMBL2096776 | — | — | 1 | 5.39 |
| CHEMBL183760 | — | — | 1 | 5.38 |
| CHEMBL360690 | — | — | 1 | 5.35 |
| CHEMBL360046 | — | — | 1 | 5.31 |
| CHEMBL360880 | — | — | 1 | 5.26 |
| CHEMBL182078 | — | — | 1 | 5.24 |
| CHEMBL167071 | — | — | 1 | 5.21 |
| CHEMBL361397 | — | — | 1 | 5.19 |
| CHEMBL166513 | — | — | 1 | 5.15 |
| CHEMBL359479 | — | — | 1 | 5.02 |
| CHEMBL180131 | — | — | 1 | 4.74 |
| CHEMBL183564 | — | — | 1 | 4.72 |
| CHEMBL354345 | — | — | 1 | 4.67 |
| CHEMBL183120 | — | — | 1 | - |
| CHEMBL182295 | — | — | 1 | - |
| CHEMBL360292 | — | — | 1 | - |
| CHEMBL182096 | — | — | 1 | - |
| CHEMBL362695 | — | — | 1 | - |
| CHEMBL367365 | — | — | 1 | - |
| CHEMBL182563 | — | — | 1 | - |
| CHEMBL183655 | — | — | 1 | - |
| CHEMBL181355 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183619 | — | IC50 | = | 675.0 | nM | 6.17 |
| CHEMBL183109 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL183379 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL361111 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL182095 | — | IC50 | = | 3015.0 | nM | 5.52 |
| CHEMBL82932 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL82932 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL2096776 | — | IC50 | = | 4060.0 | nM | 5.39 |
| CHEMBL183760 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL360690 | — | IC50 | = | 4490.0 | nM | 5.35 |
| CHEMBL360046 | — | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL360880 | — | IC50 | = | 5450.0 | nM | 5.26 |
| CHEMBL182078 | — | IC50 | = | 5810.0 | nM | 5.24 |
| CHEMBL167071 | — | IC50 | = | 6190.0 | nM | 5.21 |
| CHEMBL361397 | — | IC50 | = | 6505.0 | nM | 5.19 |
| CHEMBL166513 | — | IC50 | = | 7070.0 | nM | 5.15 |
| CHEMBL359479 | — | IC50 | = | 9590.0 | nM | 5.02 |
| CHEMBL180131 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL183564 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL354345 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL183120 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL183109 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL360292 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL182096 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL362695 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL367365 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL182563 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL183655 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL181355 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL182295 | — | IC50 | > | 10000.0 | nM | - |