Assay Detail
Binding
CHEMBL828522
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Inhibitory activity against recombinant human Caspase-8
30
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.60 | 7.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183109 | — | — | 2 | 7.04 |
| CHEMBL183619 | — | — | 1 | 7.01 |
| CHEMBL183379 | — | — | 1 | 6.98 |
| CHEMBL361111 | — | — | 1 | 6.55 |
| CHEMBL360046 | — | — | 1 | 6.20 |
| CHEMBL360690 | — | — | 1 | 6.01 |
| CHEMBL183760 | — | — | 1 | 5.94 |
| CHEMBL182096 | — | — | 1 | 5.88 |
| CHEMBL361397 | — | — | 1 | 5.79 |
| CHEMBL82932 | — | — | 2 | 5.72 |
| CHEMBL360880 | — | — | 1 | 5.48 |
| CHEMBL2096776 | — | — | 1 | 5.44 |
| CHEMBL167071 | — | — | 1 | 5.41 |
| CHEMBL181355 | — | — | 1 | 5.35 |
| CHEMBL182295 | — | — | 1 | 5.27 |
| CHEMBL182078 | — | — | 1 | 5.23 |
| CHEMBL362695 | — | — | 1 | 5.14 |
| CHEMBL182095 | — | — | 1 | 5.13 |
| CHEMBL183564 | — | — | 1 | 5.10 |
| CHEMBL166513 | — | — | 1 | 5.10 |
| CHEMBL360292 | — | — | 1 | 5.04 |
| CHEMBL183655 | — | — | 1 | 5.02 |
| CHEMBL359479 | — | — | 1 | 4.91 |
| CHEMBL180131 | — | — | 1 | 4.86 |
| CHEMBL354345 | — | — | 1 | 4.66 |
| CHEMBL367365 | — | — | 1 | - |
| CHEMBL182563 | — | — | 1 | - |
| CHEMBL183120 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183109 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL183619 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL183379 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL361111 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL360046 | — | IC50 | = | 635.0 | nM | 6.20 |
| CHEMBL360690 | — | IC50 | = | 975.0 | nM | 6.01 |
| CHEMBL183760 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL182096 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL361397 | — | IC50 | = | 1625.0 | nM | 5.79 |
| CHEMBL82932 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL82932 | — | IC50 | = | 1885.0 | nM | 5.72 |
| CHEMBL360880 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL2096776 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL167071 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL181355 | — | IC50 | = | 4505.0 | nM | 5.35 |
| CHEMBL183109 | — | IC50 | = | 4470.0 | nM | 5.35 |
| CHEMBL182295 | — | IC50 | = | 5380.0 | nM | 5.27 |
| CHEMBL182078 | — | IC50 | = | 5830.0 | nM | 5.23 |
| CHEMBL362695 | — | IC50 | = | 7270.0 | nM | 5.14 |
| CHEMBL182095 | — | IC50 | = | 7340.0 | nM | 5.13 |
| CHEMBL166513 | — | IC50 | = | 7910.0 | nM | 5.10 |
| CHEMBL183564 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL360292 | — | IC50 | = | 9175.0 | nM | 5.04 |
| CHEMBL183655 | — | IC50 | = | 9580.0 | nM | 5.02 |
| CHEMBL359479 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL180131 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL354345 | — | IC50 | = | 22050.0 | nM | 4.66 |
| CHEMBL182563 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL367365 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL183120 | — | IC50 | > | 10000.0 | nM | - |