Assay Detail
Binding
CHEMBL828540
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for human Estrogen receptor beta
14
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-based virtual screening for plant-based ERbeta-selective ligands as potential preventative therapy against age-related neurodegenerative diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.11 | 7.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30707 | COUMESTROL | — | 2 | 7.73 |
| CHEMBL44 | GENISTEIN | 2.0 | 2 | 7.01 |
| CHEMBL193518 | — | — | 2 | 6.60 |
| CHEMBL195560 | ISOPHENOXODIOL | 3.0 | 2 | 6.17 |
| CHEMBL8145 | DAIDZEIN | 2.0 | 2 | 5.55 |
| CHEMBL424829 | — | — | 2 | 5.35 |
| CHEMBL370039 | — | — | 2 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30707 | COUMESTROL | IC50 | = | 18.6 | nM | 7.73 |
| CHEMBL30707 | COUMESTROL | IC50 | = | 18.6 | nM | 7.73 |
| CHEMBL44 | GENISTEIN | IC50 | = | 98.7 | nM | 7.01 |
| CHEMBL44 | GENISTEIN | IC50 | = | 98.7 | nM | 7.01 |
| CHEMBL193518 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL193518 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL195560 | ISOPHENOXODIOL | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL195560 | ISOPHENOXODIOL | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL8145 | DAIDZEIN | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL8145 | DAIDZEIN | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL424829 | — | IC50 | = | 4480.0 | nM | 5.35 |
| CHEMBL424829 | — | IC50 | = | 4480.0 | nM | 5.35 |
| CHEMBL370039 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL370039 | — | IC50 | = | 43000.0 | nM | 4.37 |