Assay Detail
Binding
CHEMBL828554
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Inhibitory concentration against monoamine oxidase A in rat brain mitochondrial suspension
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Sulfur-substituted alpha-alkyl phenethylamines as selective and reversible MAO-A inhibitors: biological activities, CoMFA analysis, and active site modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.59 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190095 | — | — | 1 | 7.16 |
| CHEMBL190331 | — | — | 1 | 7.10 |
| CHEMBL193309 | — | — | 1 | 7.00 |
| CHEMBL161985 | — | — | 1 | 6.70 |
| CHEMBL6467 | 4-METHYLTHIOAMPHETAMINE | — | 1 | 6.70 |
| CHEMBL189835 | — | — | 1 | 6.52 |
| CHEMBL189630 | — | — | 1 | 6.52 |
| CHEMBL278663 | PARA-METHOXYAMPHETAMINE | — | 1 | 6.52 |
| CHEMBL191132 | — | — | 1 | 6.40 |
| CHEMBL34108 | — | — | 1 | 6.40 |
| CHEMBL282734 | — | — | 1 | 6.22 |
| CHEMBL190164 | — | — | 1 | 5.85 |
| CHEMBL193215 | — | — | 1 | 5.85 |
| CHEMBL190857 | — | — | 1 | 5.75 |
| CHEMBL341318 | — | — | 1 | 5.62 |
| CHEMBL192578 | — | — | 1 | 5.54 |
| CHEMBL339611 | — | — | 1 | 5.42 |
| CHEMBL358967 | — | — | 1 | 5.40 |
| CHEMBL193045 | — | — | 1 | 5.35 |
| CHEMBL447830 | — | — | 1 | 5.28 |
| CHEMBL190253 | — | — | 1 | 5.12 |
| CHEMBL31557 | — | — | 1 | 5.03 |
| CHEMBL426457 | — | — | 1 | 4.96 |
| CHEMBL372719 | — | — | 1 | 4.93 |
| CHEMBL33867 | — | — | 1 | 4.89 |
| CHEMBL193154 | — | — | 1 | 4.84 |
| CHEMBL189916 | — | — | 1 | 4.81 |
| CHEMBL277540 | — | — | 1 | 4.70 |
| CHEMBL8600 | DOM | — | 1 | 4.62 |
| CHEMBL127653 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190095 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL190331 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL193309 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL161985 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL6467 | 4-METHYLTHIOAMPHETAMINE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL189835 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL189630 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL278663 | PARA-METHOXYAMPHETAMINE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL191132 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL34108 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL282734 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL190164 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL193215 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL190857 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL341318 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL192578 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL339611 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL358967 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL193045 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL447830 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL190253 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL31557 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL426457 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL372719 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL33867 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL193154 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL189916 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL277540 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL8600 | DOM | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL127653 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL192944 | — | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL6616 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL6607 | BROLAMFETAMINE | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL193301 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL8642 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL6620 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL8301 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL8028 | — | IC50 | > | 100000.0 | nM | - |