Assay Detail
Binding
CHEMBL828561
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Inhibitory concentration against steroid sulfatase in placental microsomes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Placenta |
| Subcellular | Microsomes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.75 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122708 | EMATE | — | 1 | 7.66 |
| CHEMBL190628 | — | — | 1 | 7.47 |
| CHEMBL372231 | — | — | 1 | 7.38 |
| CHEMBL362734 | — | — | 1 | 6.92 |
| CHEMBL366144 | — | — | 1 | 6.05 |
| CHEMBL366014 | — | — | 1 | 6.00 |
| CHEMBL190451 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122708 | EMATE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL190628 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL372231 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL362734 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL366144 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL366014 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL190451 | — | IC50 | = | 1800.0 | nM | 5.75 |