Assay Detail
Binding
CHEMBL828563
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Inhibitory concentration against Fatty-acid amide hydrolase
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.38 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL367966 | — | — | 1 | 9.52 |
| CHEMBL175854 | — | — | 1 | 9.00 |
| CHEMBL177577 | — | — | 1 | 8.70 |
| CHEMBL175580 | — | — | 1 | 8.70 |
| CHEMBL174397 | — | — | 1 | 7.70 |
| CHEMBL35925 | — | — | 1 | 7.40 |
| CHEMBL426230 | — | — | 1 | 6.82 |
| CHEMBL91417 | — | — | 1 | 5.70 |
| CHEMBL39412 | — | — | 1 | 5.70 |
| CHEMBL422064 | — | — | 1 | 5.35 |
| CHEMBL413727 | — | — | 1 | 5.30 |
| CHEMBL91416 | — | — | 1 | 5.30 |
| CHEMBL89946 | — | — | 1 | 5.19 |
| CHEMBL285678 | — | — | 1 | 5.00 |
| CHEMBL366907 | — | — | 1 | 5.00 |
| CHEMBL90308 | — | — | 1 | 5.00 |
| CHEMBL90258 | — | — | 1 | 5.00 |
| CHEMBL93675 | — | — | 1 | 4.52 |
| CHEMBL293277 | — | — | 1 | - |
| CHEMBL292454 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL367966 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL175854 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL177577 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL175580 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL174397 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL35925 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL426230 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL91417 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL39412 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL422064 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL413727 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL91416 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL89946 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL285678 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL366907 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL90308 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL90258 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL93675 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL293277 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL292454 | — | IC50 | > | 100000.0 | nM | - |