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Assay Detail

CHEMBL828573

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Binding
Inhibitory concentration against human Coagulation factor X
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Coagulation factor X (CHEMBL244)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-activity relationships of potent and selective factor Xa inhibitors: benzimidazole derivatives with the side chain oriented to the prime site of factor Xa.
Ueno H, Katoh S, Yokota K, Hoshi J, Hayashi M, Uchida I, Aisaka K, Hase Y, Cho H.
Bioorg Med Chem Lett (2004) 14 : 4281 -4286
PubMed 15261287 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 7.02 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2094062 1 8.52
CHEMBL537184 1 8.22
CHEMBL536722 1 8.00
CHEMBL536490 1 7.70
CHEMBL541371 1 7.52
CHEMBL536723 1 7.52
CHEMBL556778 1 7.40
CHEMBL555005 1 7.22
CHEMBL539053 DX-9065A HYDROCHLORIDE HYDRATE 1 7.22
CHEMBL541372 1 7.10
CHEMBL2093954 1 7.10
CHEMBL553328 1 7.00
CHEMBL556972 1 7.00
CHEMBL557179 1 7.00
CHEMBL538320 1 6.70
CHEMBL536488 1 6.70
CHEMBL538077 1 6.70
CHEMBL540869 1 6.52
CHEMBL538315 1 6.52
CHEMBL556796 1 6.40
CHEMBL536721 1 6.22
CHEMBL556971 1 5.70
CHEMBL556192 1 5.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2094062 IC50 = 3.0 nM 8.52
CHEMBL537184 IC50 = 6.0 nM 8.22
CHEMBL536722 IC50 = 10.0 nM 8.00
CHEMBL536490 IC50 = 20.0 nM 7.70
CHEMBL541371 IC50 = 30.0 nM 7.52
CHEMBL536723 IC50 = 30.0 nM 7.52
CHEMBL556778 IC50 = 40.0 nM 7.40
CHEMBL555005 IC50 = 60.0 nM 7.22
CHEMBL539053 DX-9065A HYDROCHLORIDE HYDRATE IC50 = 60.0 nM 7.22
CHEMBL541372 IC50 = 80.0 nM 7.10
CHEMBL2093954 IC50 = 80.0 nM 7.10
CHEMBL553328 IC50 = 100.0 nM 7.00
CHEMBL556972 IC50 = 100.0 nM 7.00
CHEMBL557179 IC50 = 100.0 nM 7.00
CHEMBL538320 IC50 = 200.0 nM 6.70
CHEMBL536488 IC50 = 200.0 nM 6.70
CHEMBL538077 IC50 = 200.0 nM 6.70
CHEMBL540869 IC50 = 300.0 nM 6.52
CHEMBL538315 IC50 = 300.0 nM 6.52
CHEMBL556796 IC50 = 400.0 nM 6.40
CHEMBL536721 IC50 = 600.0 nM 6.22
CHEMBL556971 IC50 = 2000.0 nM 5.70
CHEMBL556192 IC50 = 3000.0 nM 5.52