Assay Detail
Binding
CHEMBL828588
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against Enterococcus faecalis beta-Ketoacyl-acyl carrier protein synthase III
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Enterococcus faecalis |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Beta-ketoacyl-[acyl-carrier-protein] synthase III (CHEMBL5070) ↗| Type | SINGLE PROTEIN |
| Organism | Enterococcus faecalis (strain ATCC 700802 / V583) |
Publication
Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 5.96 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370931 | — | — | 1 | 8.40 |
| CHEMBL180466 | — | — | 1 | 7.55 |
| CHEMBL175848 | — | — | 1 | 7.25 |
| CHEMBL191827 | — | — | 1 | 7.21 |
| CHEMBL179596 | — | — | 1 | 7.02 |
| CHEMBL179595 | — | — | 1 | 6.96 |
| CHEMBL195658 | — | — | 1 | 6.80 |
| CHEMBL180271 | — | — | 1 | 6.80 |
| CHEMBL179573 | — | — | 1 | 6.66 |
| CHEMBL369324 | — | — | 1 | 6.62 |
| CHEMBL359673 | — | — | 1 | 6.60 |
| CHEMBL361554 | — | — | 1 | 6.57 |
| CHEMBL179235 | — | — | 1 | 6.54 |
| CHEMBL426597 | — | — | 1 | 6.48 |
| CHEMBL193840 | — | — | 1 | 6.39 |
| CHEMBL178754 | — | — | 1 | 6.39 |
| CHEMBL179678 | — | — | 1 | 6.33 |
| CHEMBL179541 | — | — | 1 | 6.24 |
| CHEMBL179912 | — | — | 1 | 6.10 |
| CHEMBL178585 | — | — | 1 | 5.96 |
| CHEMBL180228 | — | — | 1 | 5.92 |
| CHEMBL175611 | — | — | 1 | 5.80 |
| CHEMBL178657 | — | — | 1 | 5.80 |
| CHEMBL362422 | — | — | 1 | 5.68 |
| CHEMBL180277 | — | — | 1 | 5.68 |
| CHEMBL178623 | — | — | 1 | 5.66 |
| CHEMBL178465 | — | — | 1 | 5.57 |
| CHEMBL179454 | — | — | 1 | 5.50 |
| CHEMBL434177 | — | — | 1 | 5.43 |
| CHEMBL180428 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370931 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL180466 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL175848 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL191827 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL179596 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL179595 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL195658 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL180271 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL179573 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL369324 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL359673 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL361554 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL179235 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL426597 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL178754 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL193840 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL179678 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL179541 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL179912 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL178585 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL180228 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL175611 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL178657 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL362422 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL180277 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL178623 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL178465 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL179454 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL434177 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL180428 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL193374 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL191960 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL426645 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL178739 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL178382 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL179033 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL438975 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL180162 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL178517 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL179049 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL180223 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL179418 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL193491 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL361610 | — | IC50 | = | 160000.0 | nM | - |
| CHEMBL179402 | — | IC50 | = | 290000.0 | nM | - |
| CHEMBL178832 | — | IC50 | = | 185000.0 | nM | - |