Assay Detail
Binding
CHEMBL828593
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Inhibitory concentration against [3H]1 binding to recombinant human Metabotropic glutamate receptor 8
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
(2S,1'S,2'R,3'R)-2(2'-Carboxy-3'-hydroxymethylcyclopropyl)glycine-[3H], a potent and selective radioligand for labeling group 2 and 3 metabotropic glutamate receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.27 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285843 | — | — | 1 | 8.29 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 8.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285843 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL575060 | GLUTAMIC ACID | IC50 | = | 5.7 | nM | 8.24 |