Assay Detail
Binding
CHEMBL828612
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of type-3 17 beta-hydroxysteroid dehydrogenase expressed in HEK293 cells at 37 degree C pH7.4
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
17-beta-hydroxysteroid dehydrogenase type 3 (CHEMBL4234) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Androsterone 3alpha-ether-3beta-substituted and androsterone 3beta-substituted derivatives as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase: chemical synthesis and structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.89 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137852 | — | — | 1 | 7.24 |
| CHEMBL3138113 | — | — | 1 | 7.22 |
| CHEMBL3137851 | — | — | 1 | 7.17 |
| CHEMBL3138219 | — | — | 1 | 7.14 |
| CHEMBL3138082 | — | — | 1 | 7.14 |
| CHEMBL3138431 | — | — | 1 | 7.09 |
| CHEMBL3137857 | — | — | 1 | 7.06 |
| CHEMBL3138210 | — | — | 1 | 7.01 |
| CHEMBL3137845 | — | — | 1 | 7.00 |
| CHEMBL3137856 | — | — | 1 | 7.00 |
| CHEMBL3138330 | — | — | 1 | 6.94 |
| CHEMBL3138065 | — | — | 1 | 6.85 |
| CHEMBL3138209 | — | — | 1 | 6.83 |
| CHEMBL3138398 | — | — | 1 | 6.81 |
| CHEMBL85799 | ETIOCHOLANOLONE | — | 1 | 6.48 |
| CHEMBL3138336 | — | — | 1 | 6.45 |
| CHEMBL3138074 | — | — | 1 | 6.45 |
| CHEMBL274826 | ANDROSTENEDIONE | -1.0 | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137852 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL3138113 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3137851 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL3138219 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL3138082 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL3138431 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL3137857 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL3138210 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL3137845 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL3137856 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3138330 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL3138065 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL3138209 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL3138398 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL85799 | ETIOCHOLANOLONE | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3138336 | — | IC50 | = | 352.0 | nM | 6.45 |
| CHEMBL3138074 | — | IC50 | = | 354.0 | nM | 6.45 |
| CHEMBL274826 | ANDROSTENEDIONE | IC50 | = | 758.0 | nM | 6.12 |