Assay Detail
Binding
CHEMBL828680
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Inhibitory concentration against human recombinant metabotropic glutamate receptor 5 (mGlu5) in Ltk cells determined using fluorescence detection method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Ltk |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.22 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361973 | — | — | 1 | 8.30 |
| CHEMBL292065 | — | — | 1 | 8.30 |
| CHEMBL180964 | — | — | 1 | 8.15 |
| CHEMBL180713 | — | — | 1 | 8.10 |
| CHEMBL361556 | — | — | 1 | 7.96 |
| CHEMBL181769 | — | — | 1 | 7.96 |
| CHEMBL182762 | — | — | 1 | 7.92 |
| CHEMBL181332 | — | — | 1 | 7.68 |
| CHEMBL181424 | — | — | 1 | 7.66 |
| CHEMBL181169 | — | — | 1 | 7.64 |
| CHEMBL183081 | — | — | 1 | 7.55 |
| CHEMBL441117 | — | — | 1 | 7.50 |
| CHEMBL359893 | — | — | 1 | 6.99 |
| CHEMBL178854 | — | — | 1 | 6.98 |
| CHEMBL178328 | — | — | 1 | 6.87 |
| CHEMBL179387 | — | — | 1 | 6.84 |
| CHEMBL367145 | — | — | 1 | 6.80 |
| CHEMBL178683 | — | — | 1 | 6.78 |
| CHEMBL178841 | — | — | 1 | 6.59 |
| CHEMBL361116 | — | — | 1 | 5.45 |
| CHEMBL181610 | — | — | 1 | 5.42 |
| CHEMBL178530 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361973 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL292065 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL180964 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL180713 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL361556 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL181769 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL182762 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL181332 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL181424 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL181169 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL183081 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL441117 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL359893 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL178854 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL178328 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL179387 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL367145 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL178683 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL178841 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL361116 | — | IC50 | = | 3536.0 | nM | 5.45 |
| CHEMBL181610 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL178530 | — | IC50 | = | 5084.0 | nM | 5.29 |