Compound Detail
CHEMBL178841
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Basic Information
| ChEMBL ID | CHEMBL178841 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZBPVIHJRINAVPO-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
234.7
MW (Da)
1.78
ALogP
4
HBA
1
HBD
67.8
PSA (Ų)
0.86
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.59
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 5 CHEMBL3227 | IC50 | 6.59 | 6.59 | 254.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 5 | IC50 | = | 254.0 | nM | 6.59 | Inhibitory concentration against human recombinant metabotropic glutamate recept... | 15686941 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15686941 | 10.1016/j.bmcl.2004.11.078 | Metabotropic glutamate receptor 5 | 1 |
Data from ChEMBL 36 via Core Engine