Assay Detail
Binding
CHEMBL828686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 71 pM [125I]BH-(Thr,Nle)CCK-9 binding to rat cholecystokinin 1 receptor
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Cholecystokinin receptor type A (CHEMBL2871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Combination of molecular modeling, site-directed mutagenesis, and SAR studies to delineate the binding site of pyridopyrimidine antagonists on the human CCK1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.89 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363916 | — | — | 2 | 10.05 |
| CHEMBL366344 | — | — | 2 | 9.23 |
| CHEMBL113718 | IQM-95333 | — | 1 | 8.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363916 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL366344 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL113718 | IQM-95333 | IC50 | = | 1.59 | nM | 8.80 |
| CHEMBL363916 | — | IC50 | = | 2.83 | nM | 8.55 |
| CHEMBL366344 | — | IC50 | = | 15.4 | nM | 7.81 |