Assay Detail
Binding
CHEMBL828723
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of poly(L-glutamic acid-L-tyrosine) phosphorylation by EGFR tyrosine kinase of A431 carcinoma cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis of half-mustard combi-molecules with fluorescence properties: correlation with EGFR status.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.41 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL181617 | — | — | 1 | 8.00 |
| CHEMBL179451 | — | — | 1 | 7.58 |
| CHEMBL52765 | — | — | 1 | 7.36 |
| CHEMBL343352 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL181617 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL179451 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL52765 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL343352 | — | IC50 | = | 200.0 | nM | 6.70 |