Assay Detail
Binding
CHEMBL828757
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptor
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.28 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.54 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.49 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 8.42 |
| CHEMBL654 | MIRTAZAPINE | 4.0 | 1 | 7.75 |
| CHEMBL435301 | — | — | 1 | 7.58 |
| CHEMBL193639 | — | — | 2 | 7.23 |
| CHEMBL329566 | — | — | 1 | 7.16 |
| CHEMBL363581 | — | — | 1 | 7.11 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.09 |
| CHEMBL366164 | — | — | 1 | 7.03 |
| CHEMBL194659 | — | — | 1 | 6.70 |
| CHEMBL195706 | — | — | 1 | 6.66 |
| CHEMBL364270 | — | — | 1 | 6.17 |
| CHEMBL193435 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL85 | RISPERIDONE | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL6437 | MIANSERIN | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL654 | MIRTAZAPINE | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL435301 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL193639 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL329566 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL193639 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL363581 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL715 | OLANZAPINE | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL366164 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL194659 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL195706 | — | Ki | = | 219.0 | nM | 6.66 |
| CHEMBL364270 | — | Ki | = | 677.0 | nM | 6.17 |
| CHEMBL193435 | — | Ki | = | 742.0 | nM | 6.13 |