Assay Detail
Binding
CHEMBL828775
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition constant against human intestinal carboxylesterase 2 using CPT-11
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.09 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191847 | — | — | 1 | 7.47 |
| CHEMBL362996 | — | — | 1 | 7.41 |
| CHEMBL193140 | — | — | 1 | 7.04 |
| CHEMBL192180 | — | — | 1 | 6.77 |
| CHEMBL189886 | BENZIL | — | 1 | 6.76 |
| CHEMBL192139 | — | — | 1 | - |
| CHEMBL193228 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191847 | — | Ki | = | 33.8 | nM | 7.47 |
| CHEMBL362996 | — | Ki | = | 39.1 | nM | 7.41 |
| CHEMBL193140 | — | Ki | = | 91.9 | nM | 7.04 |
| CHEMBL192180 | — | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL189886 | BENZIL | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL192139 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL193228 | — | Ki | > | 100000.0 | nM | - |