Assay Detail
Binding
CHEMBL828786
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In vitro ability to inhibit [3H]6b binding to human Dopamine receptor D4.4
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and activity of 2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide: a selective dopamine D4 receptor agonist and radioligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.59 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184486 | — | — | 1 | 8.74 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.72 |
| CHEMBL184853 | — | — | 1 | 7.85 |
| CHEMBL362542 | — | — | 1 | 7.84 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.52 |
| CHEMBL182432 | — | — | 1 | 7.41 |
| CHEMBL184772 | — | — | 1 | 7.05 |
| CHEMBL185263 | — | — | 1 | 7.04 |
| CHEMBL183466 | — | — | 1 | 6.95 |
| CHEMBL363308 | — | — | 1 | 6.76 |
| CHEMBL184263 | — | — | 1 | - |
| CHEMBL183601 | — | — | 1 | - |
| CHEMBL364865 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184486 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL184853 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL362542 | — | Ki | = | 14.5 | nM | 7.84 |
| CHEMBL42 | CLOZAPINE | Ki | = | 30.4 | nM | 7.52 |
| CHEMBL182432 | — | Ki | = | 39.1 | nM | 7.41 |
| CHEMBL184772 | — | Ki | = | 88.9 | nM | 7.05 |
| CHEMBL185263 | — | Ki | = | 90.7 | nM | 7.04 |
| CHEMBL183466 | — | Ki | = | 113.5 | nM | 6.95 |
| CHEMBL363308 | — | Ki | = | 174.5 | nM | 6.76 |
| CHEMBL184263 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL183601 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL364865 | — | Ki | > | 10000.0 | nM | - |