Assay Detail
Binding
CHEMBL828817
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity for rat Muscarinic acetylcholine receptor M3
19
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M3 (CHEMBL320) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design, synthesis and activity of novel derivatives of oxybutynin and tolterodine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.15 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1231 | OXYBUTYNIN | 4.0 | 1 | 9.02 |
| CHEMBL1382 | TOLTERODINE | 4.0 | 1 | 8.15 |
| CHEMBL192065 | — | — | 1 | 7.85 |
| CHEMBL192061 | — | — | 2 | 7.60 |
| CHEMBL192537 | — | — | 1 | 7.46 |
| CHEMBL192485 | — | — | 2 | 7.43 |
| CHEMBL192337 | — | — | 1 | 7.41 |
| CHEMBL190815 | — | — | 1 | 7.30 |
| CHEMBL192885 | — | — | 1 | 6.93 |
| CHEMBL195169 | — | — | 1 | 6.54 |
| CHEMBL194870 | — | — | 1 | 6.44 |
| CHEMBL190459 | — | — | 1 | 6.02 |
| CHEMBL424832 | — | — | 1 | 5.58 |
| CHEMBL372462 | — | — | 1 | - |
| CHEMBL363865 | — | — | 1 | - |
| CHEMBL370757 | — | — | 1 | - |
| CHEMBL192083 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1231 | OXYBUTYNIN | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL1382 | TOLTERODINE | Ki | = | 7.07 | nM | 8.15 |
| CHEMBL192065 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL192061 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL192537 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL192485 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL192337 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL190815 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL192061 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL192885 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL195169 | — | Ki | = | 291.0 | nM | 6.54 |
| CHEMBL192485 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL194870 | — | Ki | = | 366.0 | nM | 6.44 |
| CHEMBL190459 | — | Ki | = | 964.0 | nM | 6.02 |
| CHEMBL424832 | — | Ki | = | 2605.0 | nM | 5.58 |
| CHEMBL372462 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL363865 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL370757 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL192083 | — | Ki | > | 10000.0 | nM | - |