Assay Detail
Binding
CHEMBL828825
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Inhibitory constant against carbonic anhydrase IV
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 4.52 | 4.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185198 | CYNOOXIDE ANION | — | 1 | 4.52 |
| CHEMBL1231821 | HYDROCHLORIC ACID | -1.0 | 1 | - |
| CHEMBL1231461 | BROMIDE | — | 1 | - |
| CHEMBL1233550 | IODIDE | -1.0 | 1 | - |
| CHEMBL1161632 | BICARBONATE | 3.0 | 1 | - |
| CHEMBL572964 | SULFURIC ACID | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185198 | CYNOOXIDE ANION | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL1231821 | HYDROCHLORIC ACID | Ki | = | 36000000.0 | nM | - |
| CHEMBL1231461 | BROMIDE | Ki | = | 52000000.0 | nM | - |
| CHEMBL1233550 | IODIDE | Ki | = | 11000000.0 | nM | - |
| CHEMBL1161632 | BICARBONATE | Ki | = | 44000000.0 | nM | - |
| CHEMBL572964 | SULFURIC ACID | Ki | = | 44000000.0 | nM | - |