Assay Detail
Binding
CHEMBL828840
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Inhibition of [3H]DAMGO ([D-Ala2,NMePhe4,glyol]-enkephalin) binding to mu opioid receptor expressed in CHO cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
[Nalpha-benzylTyr1,cyclo(D-Asp5,Dap8)]- dynorphin A-(1-11)NH2 cyclized in the "address" domain is a novel kappa-opioid receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.70 | 8.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216640 | — | — | 1 | 8.73 |
| CHEMBL584594 | — | — | 1 | 7.07 |
| CHEMBL406229 | — | — | 1 | 5.78 |
| CHEMBL263590 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216640 | — | Ki | = | 1.85 | nM | 8.73 |
| CHEMBL584594 | — | Ki | = | 84.9 | nM | 7.07 |
| CHEMBL406229 | — | Ki | = | 1658.0 | nM | 5.78 |
| CHEMBL263590 | — | Ki | = | 5880.0 | nM | 5.23 |