Assay Detail
Binding
CHEMBL828882
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Inhibition of [3H]nisoxetine binding to rat Norepinephrine transporter
16
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.44 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193639 | — | — | 2 | 8.80 |
| CHEMBL363581 | — | — | 1 | 8.57 |
| CHEMBL194659 | — | — | 1 | 8.44 |
| CHEMBL329566 | — | — | 1 | 8.11 |
| CHEMBL435301 | — | — | 1 | 8.03 |
| CHEMBL195706 | — | — | 1 | 7.70 |
| CHEMBL366164 | — | — | 1 | 7.40 |
| CHEMBL364270 | — | — | 1 | 7.06 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 7.00 |
| CHEMBL193435 | — | — | 1 | 6.42 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.16 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 6.02 |
| CHEMBL654 | MIRTAZAPINE | 4.0 | 1 | 5.79 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | - |
| CHEMBL195856 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193639 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL193639 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL363581 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL194659 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL329566 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL435301 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL195706 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL366164 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL364270 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL6437 | MIANSERIN | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL193435 | — | Ki | = | 382.0 | nM | 6.42 |
| CHEMBL42 | CLOZAPINE | Ki | = | 697.0 | nM | 6.16 |
| CHEMBL715 | OLANZAPINE | Ki | = | 958.0 | nM | 6.02 |
| CHEMBL654 | MIRTAZAPINE | Ki | = | 1640.0 | nM | 5.79 |
| CHEMBL85 | RISPERIDONE | Ki | > | 5454.0 | nM | - |
| CHEMBL195856 | — | Ki | > | 5454.0 | nM | - |