Assay Detail
Binding
CHEMBL828889
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Binding affinity was determined against human gonadotropin-releasing hormone receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Gonadotropin-releasing hormone receptor (CHEMBL1855) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Efficient synthesis of bicyclic oxazolino- and thiazolino[3,2-c]pyrimidine-5,7-diones and its application to the synthesis of GnRH antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.12 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359894 | — | — | 1 | 8.64 |
| CHEMBL360126 | — | — | 1 | 8.35 |
| CHEMBL112466 | — | — | 1 | 8.26 |
| CHEMBL362237 | — | — | 1 | 7.40 |
| CHEMBL181945 | — | — | 1 | 7.03 |
| CHEMBL179101 | — | — | 1 | 6.96 |
| CHEMBL425529 | — | — | 1 | 6.90 |
| CHEMBL362283 | — | — | 1 | 6.66 |
| CHEMBL362025 | — | — | 1 | 6.64 |
| CHEMBL178961 | — | — | 1 | 6.34 |
| CHEMBL361619 | — | — | 1 | 6.16 |
| CHEMBL181582 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359894 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL360126 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL112466 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL362237 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL181945 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL179101 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL425529 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL362283 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL362025 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL178961 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL361619 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL181582 | — | Ki | = | 870.0 | nM | 6.06 |