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Assay Detail

CHEMBL828902

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of coagulation factor II (thrombin) of human
23
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Prothrombin (CHEMBL204)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

9-hydroxyazafluorenes and their use in thrombin inhibitors.
Stauffer KJ, Williams PD, Selnick HG, Nantermet PG, Newton CL, Homnick CF, Zrada MM, Lewis SD, Lucas BJ, Krueger JA, Pietrak BL, Lyle EA, Singh R, Miller-Stein C, White RB, Wong B, Wallace AA, Sitko GR, Cook JJ, Holahan MA, Stranieri-Michener M, Leonard YM, Lynch JJ, McMasters DR, Yan Y.
J Med Chem (2005) 48 : 2282 -2293
PubMed 15801822 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 23 8.75 10.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL191441 2 10.38
CHEMBL192378 2 9.70
CHEMBL192721 2 9.60
CHEMBL372036 2 9.52
CHEMBL372449 2 9.40
CHEMBL190075 1 9.31
CHEMBL191062 1 9.26
CHEMBL192268 2 9.11
CHEMBL190687 2 9.11
CHEMBL426806 2 9.01
CHEMBL364255 1 8.82
CHEMBL190491 2 8.68
CHEMBL193188 1 8.51
CHEMBL193781 1 6.26

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL191441 Ki = 0.042 nM 10.38
CHEMBL192378 Ki = 0.2 nM 9.70
CHEMBL192721 Ki = 0.25 nM 9.60
CHEMBL372036 Ki = 0.3 nM 9.52
CHEMBL372449 Ki = 0.4 nM 9.40
CHEMBL190075 Ki = 0.49 nM 9.31
CHEMBL191062 Ki = 0.55 nM 9.26
CHEMBL192268 Ki = 0.78 nM 9.11
CHEMBL190687 Ki = 0.77 nM 9.11
CHEMBL426806 Ki = 0.98 nM 9.01
CHEMBL191441 Ki = 1.1 nM 8.96
CHEMBL192268 Ki = 1.4 nM 8.85
CHEMBL364255 Ki = 1.5 nM 8.82
CHEMBL372449 Ki = 2.0 nM 8.70
CHEMBL190491 Ki = 2.1 nM 8.68
CHEMBL193188 Ki = 3.1 nM 8.51
CHEMBL372036 Ki = 3.2 nM 8.49
CHEMBL192378 Ki = 3.3 nM 8.48
CHEMBL190491 Ki = 3.3 nM 8.48
CHEMBL190687 Ki = 4.4 nM 8.36
CHEMBL426806 Ki = 37.0 nM 7.43
CHEMBL192721 Ki = 140.0 nM 6.85
CHEMBL193781 Ki = 550.0 nM 6.26