Assay Detail
Binding
CHEMBL828940
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Inhibition of GR-mediated tyrosine amino transferase activity in human HepG2 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.44 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 7.62 |
| CHEMBL310570 | — | — | 1 | 7.44 |
| CHEMBL372684 | — | — | 1 | 6.45 |
| CHEMBL313062 | — | — | 1 | 6.28 |
| CHEMBL82546 | — | — | 1 | 6.00 |
| CHEMBL193404 | — | — | 1 | 5.97 |
| CHEMBL364015 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131 | PREDNISOLONE | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL310570 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL372684 | — | EC50 | = | 356.0 | nM | 6.45 |
| CHEMBL313062 | — | EC50 | = | 521.0 | nM | 6.28 |
| CHEMBL82546 | — | EC50 | = | 1004.0 | nM | 6.00 |
| CHEMBL193404 | — | EC50 | = | 1068.0 | nM | 5.97 |
| CHEMBL364015 | — | EC50 | = | 4443.0 | nM | 5.35 |