Assay Detail
Binding
CHEMBL828965
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Binding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Piperazinebenzylamines as potent and selective antagonists of the human melanocortin-4 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.83 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186083 | — | — | 1 | 6.00 |
| CHEMBL186289 | — | — | 1 | 5.85 |
| CHEMBL186074 | — | — | 1 | 5.85 |
| CHEMBL364215 | — | — | 1 | 5.75 |
| CHEMBL390130 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186083 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL186289 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL186074 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL364215 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL390130 | — | Ki | = | 1900.0 | nM | 5.72 |