Assay Detail
Binding
CHEMBL828968
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]flunitrazepam from central benzodiazepine GABA-A receptor of rat cerebral cortex
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationships and effects on neuroactive steroid synthesis in a series of 2-phenylimidazo[1,2-a]pyridineacetamide peripheral benzodiazepine receptors ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 5.29 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179432 | — | — | 1 | 7.16 |
| CHEMBL179711 | — | — | 1 | 6.89 |
| CHEMBL359593 | — | — | 1 | 6.30 |
| CHEMBL179476 | — | — | 1 | 5.59 |
| CHEMBL180279 | — | — | 1 | 5.16 |
| CHEMBL180377 | — | — | 1 | 5.16 |
| CHEMBL361968 | — | — | 1 | 5.16 |
| CHEMBL179459 | — | — | 1 | 5.16 |
| CHEMBL180210 | — | — | 1 | 5.16 |
| CHEMBL178705 | — | — | 1 | 5.16 |
| CHEMBL359841 | — | — | 1 | 5.16 |
| CHEMBL2096767 | — | — | 1 | 5.16 |
| CHEMBL368040 | — | — | 1 | 5.16 |
| CHEMBL179675 | — | — | 1 | 5.16 |
| CHEMBL179748 | — | — | 1 | 5.16 |
| CHEMBL179565 | — | — | 1 | 5.16 |
| CHEMBL178518 | — | — | 1 | 5.16 |
| CHEMBL369327 | — | — | 1 | 5.16 |
| CHEMBL430139 | — | — | 1 | 5.16 |
| CHEMBL180225 | — | — | 1 | 5.15 |
| CHEMBL369753 | — | — | 1 | 5.15 |
| CHEMBL362596 | — | — | 1 | 5.15 |
| CHEMBL361857 | — | — | 1 | 5.15 |
| CHEMBL362200 | — | — | 1 | 5.15 |
| CHEMBL178778 | — | — | 1 | 5.15 |
| CHEMBL435489 | — | — | 1 | 5.15 |
| CHEMBL363217 | — | — | 1 | 5.12 |
| CHEMBL179568 | — | — | 1 | 5.12 |
| CHEMBL362037 | — | — | 1 | 5.12 |
| CHEMBL362632 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179432 | — | Ki | = | 68.9 | nM | 7.16 |
| CHEMBL179711 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL359593 | — | Ki | = | 506.0 | nM | 6.30 |
| CHEMBL179476 | — | Ki | = | 2560.0 | nM | 5.59 |
| CHEMBL180377 | — | Ki | = | 6880.0 | nM | 5.16 |
| CHEMBL361968 | — | Ki | = | 6880.0 | nM | 5.16 |
| CHEMBL179459 | — | Ki | = | 6880.0 | nM | 5.16 |
| CHEMBL180279 | — | Ki | = | 6880.0 | nM | 5.16 |
| CHEMBL180210 | — | Ki | = | 6880.0 | nM | 5.16 |
| CHEMBL178705 | — | Ki | = | 6880.0 | nM | 5.16 |
| CHEMBL359841 | — | Ki | = | 6880.0 | nM | 5.16 |
| CHEMBL2096767 | — | Ki | = | 6880.0 | nM | 5.16 |
| CHEMBL368040 | — | Ki | = | 6880.0 | nM | 5.16 |
| CHEMBL179675 | — | Ki | = | 6880.0 | nM | 5.16 |
| CHEMBL179748 | — | Ki | = | 6880.0 | nM | 5.16 |
| CHEMBL179565 | — | Ki | = | 6880.0 | nM | 5.16 |
| CHEMBL178518 | — | Ki | = | 6880.0 | nM | 5.16 |
| CHEMBL369327 | — | Ki | = | 6880.0 | nM | 5.16 |
| CHEMBL430139 | — | Ki | = | 6880.0 | nM | 5.16 |
| CHEMBL362596 | — | Ki | = | 7010.0 | nM | 5.15 |
| CHEMBL369753 | — | Ki | = | 7010.0 | nM | 5.15 |
| CHEMBL361857 | — | Ki | = | 7010.0 | nM | 5.15 |
| CHEMBL362200 | — | Ki | = | 7010.0 | nM | 5.15 |
| CHEMBL178778 | — | Ki | = | 7010.0 | nM | 5.15 |
| CHEMBL180225 | — | Ki | = | 7010.0 | nM | 5.15 |
| CHEMBL435489 | — | Ki | = | 7010.0 | nM | 5.15 |
| CHEMBL363217 | — | Ki | = | 7590.0 | nM | 5.12 |
| CHEMBL179568 | — | Ki | = | 7590.0 | nM | 5.12 |
| CHEMBL362037 | — | Ki | = | 7590.0 | nM | 5.12 |
| CHEMBL362632 | — | Ki | = | 7590.0 | nM | 5.12 |
| CHEMBL360798 | — | Ki | = | 7590.0 | nM | 5.12 |
| CHEMBL179567 | — | Ki | = | 7750.0 | nM | 5.11 |
| CHEMBL178676 | — | Ki | = | 7750.0 | nM | 5.11 |
| CHEMBL180523 | — | Ki | = | 7750.0 | nM | 5.11 |
| CHEMBL176047 | — | Ki | = | 7750.0 | nM | 5.11 |
| CHEMBL427317 | — | Ki | = | 7750.0 | nM | 5.11 |
| CHEMBL179427 | — | Ki | = | 7750.0 | nM | 5.11 |