Assay Detail
Binding
CHEMBL828979
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CGS-21680 binding to adenosine A2A receptors of bovine striatal membranes
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.07 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464859 | NECA | — | 1 | 7.80 |
| CHEMBL119709 | IB-MECA | — | 1 | 7.40 |
| CHEMBL66393 | — | — | 1 | 6.92 |
| CHEMBL2113418 | — | — | 1 | 6.66 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 6.40 |
| CHEMBL444550 | — | — | 2 | 6.33 |
| CHEMBL194031 | — | — | 1 | 5.90 |
| CHEMBL2113608 | — | — | 1 | 5.56 |
| CHEMBL2113642 | — | — | 1 | 5.50 |
| CHEMBL2113640 | — | — | 1 | 5.40 |
| CHEMBL251997 | — | — | 1 | 5.34 |
| CHEMBL606495 | — | — | 1 | 5.31 |
| CHEMBL73809 | — | — | 1 | 5.24 |
| CHEMBL400189 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464859 | NECA | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL119709 | IB-MECA | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL66393 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL2113418 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL431733 | NAMODENOSON | Ki | = | 401.0 | nM | 6.40 |
| CHEMBL444550 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL444550 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL194031 | — | Ki | = | 1260.0 | nM | 5.90 |
| CHEMBL2113608 | — | Ki | = | 2780.0 | nM | 5.56 |
| CHEMBL2113642 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL2113640 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL251997 | — | Ki | = | 4560.0 | nM | 5.34 |
| CHEMBL606495 | — | Ki | = | 4890.0 | nM | 5.31 |
| CHEMBL73809 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL400189 | — | Ki | = | 7560.0 | nM | 5.12 |