Assay Detail
Binding
CHEMBL828993
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Inhibition of [3H]-DPDPE (cyclo[D-Pen2,D-Pen5]enkep halin) binding to delta opioid receptor expressed in CHO cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
[Nalpha-benzylTyr1,cyclo(D-Asp5,Dap8)]- dynorphin A-(1-11)NH2 cyclized in the "address" domain is a novel kappa-opioid receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.27 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216640 | — | — | 1 | 8.21 |
| CHEMBL584594 | — | — | 1 | 6.32 |
| CHEMBL263590 | — | — | 1 | - |
| CHEMBL406229 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216640 | — | Ki | = | 6.18 | nM | 8.21 |
| CHEMBL584594 | — | Ki | = | 474.0 | nM | 6.32 |
| CHEMBL263590 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL406229 | — | Ki | > | 10000.0 | nM | - |