Assay Detail
Binding
CHEMBL828999
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]NBTI binding to equilibrative nucleoside transport protein 1 (ENT1) in human erythrocyte membranes
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Equilibrative nucleoside transporter 1 (CHEMBL1997) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of nucleoside transport proteins by C8-alkylamine-substituted purines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.60 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL610234 | — | — | 1 | 9.19 |
| CHEMBL608795 | — | — | 1 | 9.03 |
| CHEMBL610047 | — | — | 1 | 8.64 |
| CHEMBL607955 | — | — | 1 | 8.52 |
| CHEMBL610236 | — | — | 1 | 8.44 |
| CHEMBL610235 | — | — | 1 | 8.43 |
| CHEMBL609378 | — | — | 1 | 8.28 |
| CHEMBL608794 | — | — | 1 | 8.27 |
| CHEMBL609377 | — | — | 1 | 8.02 |
| CHEMBL609662 | — | — | 1 | 7.55 |
| CHEMBL369726 | — | — | 1 | 7.54 |
| CHEMBL361422 | — | — | 1 | 7.29 |
| CHEMBL60662 | 6-BENZYLTHIOINOSINE | — | 1 | 7.28 |
| CHEMBL178224 | — | — | 1 | 7.26 |
| CHEMBL2113438 | — | — | 1 | 7.01 |
| CHEMBL362047 | — | — | 1 | 6.87 |
| CHEMBL609376 | — | — | 1 | 6.39 |
| CHEMBL609365 | — | — | 1 | 6.13 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 5.96 |
| CHEMBL361332 | — | — | 1 | 5.82 |
| CHEMBL610237 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL610234 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL608795 | — | Ki | = | 0.94 | nM | 9.03 |
| CHEMBL610047 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL607955 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL610236 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL610235 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL609378 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL608794 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL609377 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL609662 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL369726 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL361422 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL60662 | 6-BENZYLTHIOINOSINE | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL178224 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL2113438 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL362047 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL609376 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL609365 | — | Ki | = | 744.0 | nM | 6.13 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL361332 | — | Ki | = | 1519.0 | nM | 5.82 |
| CHEMBL610237 | — | Ki | = | 33.0 | % | - |